Ontology highlight
ABSTRACT:
SUBMITTER: DiNapoli VA
PROVIDER: S-EPMC2683361 | biostudies-other | 2008 May
REPOSITORIES: biostudies-other
DiNapoli Vincent A VA Huber Jason D JD Houser Kimberly K Li Xinlan X Rosen Charles L CL
Neurobiology of aging 20070122 5
We examined the effects of age on stroke progression and outcome in order to explore the association between blood-brain barrier (BBB) disruption, neuronal damage, and functional recovery. Using middle cerebral artery occlusion (MCAO), young (3 months) and aged (18 months) rats were assessed for BBB disruption at 20min post-MCAO, and 24h post-MCAO with tissue plasminogen activator induced reperfusion at 120min. Results showed that BBB disruptions in aged rats occurred early and increased nearly ...[more]