Ontology highlight
ABSTRACT:
SUBMITTER: Fange D
PROVIDER: S-EPMC2688851 | biostudies-other | 2009 May
REPOSITORIES: biostudies-other
Proceedings of the National Academy of Sciences of the United States of America 20090501 20
Recent experiments have shown that drug efflux pump deficiency not only increases the susceptibility of pathogens to antibiotics, but also seems to "mask" the effects of mutations, that decrease the affinities of drugs to their intracellular targets, on the growth rates of drug-exposed bacteria. That is, in the presence of drugs, the growth rates of drug-exposed WT and target mutated strains are the same in a drug efflux pump deficient background, but the mutants grow faster than WT in a drug ef ...[more]