Ontology highlight
ABSTRACT:
SUBMITTER: Mythreye K
PROVIDER: S-EPMC2688894 | biostudies-other | 2009 May
REPOSITORIES: biostudies-other
Mythreye Karthikeyan K Blobe Gerard C GC
Proceedings of the National Academy of Sciences of the United States of America 20090501 20
Loss of expression of the TGF-beta superfamily coreceptor, the type III TGF-beta receptor (TbetaRIII or betaglycan), occurs in a broad spectrum of human cancers including breast, lung, ovarian, pancreatic, prostate, and renal cell cancer. TbetaRIII suppresses cancer progression in vivo, at least in part, by reducing cancer cell motility. However, the mechanism by which TbetaRIII regulates migration is unknown. Here, we demonstrate an unexpected TGF-beta signaling independent role for TbetaRIII i ...[more]