Ontology highlight
ABSTRACT:
SUBMITTER: Kawadler H
PROVIDER: S-EPMC2690087 | biostudies-other | 2008 Aug
REPOSITORIES: biostudies-other
Kawadler Holli H Gantz Mary A MA Riley James L JL Yang Xiaolu X
Molecular cell 20080801 3
Caspase-8, an initiator caspase involved in lymphocyte apoptosis, is paradoxically required for lymphocyte proliferation. It is not understood how caspase-8 is controlled during antigenic signaling to allow for activation while averting the triggering of apoptosis. Here, we show that caspase-8 undergoes limited activation upon antigenic stimulation, and this activation is dependent on the paracaspase MALT1. The paracaspase domain of MALT1, in a protease-independent manner, induces caspase-8 acti ...[more]