Ontology highlight
ABSTRACT:
SUBMITTER: Sicoli G
PROVIDER: S-EPMC2691821 | biostudies-other | 2009 Jun
REPOSITORIES: biostudies-other
Sicoli Giuseppe G Mathis Gérald G Aci-Sèche Samia S Saint-Pierre Christine C Boulard Yves Y Gasparutto Didier D Gambarelli Serge S
Nucleic acids research 20090320 10
Double electron-electron resonance (DEER) was applied to determine nanometre spin-spin distances on DNA duplexes that contain selected structural alterations. The present approach to evaluate the structural features of DNA damages is thus related to the interspin distance changes, as well as to the flexibility of the overall structure deduced from the distance distribution. A set of site-directed nitroxide-labelled double-stranded DNA fragments containing defined lesions, namely an 8-oxoguanine, ...[more]