Ontology highlight
ABSTRACT:
SUBMITTER: Movassaghi M
PROVIDER: S-EPMC2692836 | biostudies-other | 2008 Aug
REPOSITORIES: biostudies-other
Movassaghi Mohammad M Hill Matthew D MD
Organic letters 20080719 16
The direct conversion of various amides to isoquinoline and beta-carboline derivatives via mild electrophilic amide activation, with trifluoromethanesulfonic anhydride in the presence of 2-chloropyridine, is described. Low-temperature amide activation followed by cyclodehydration upon warming provides the desired products with short overall reaction times. The successful use of nonactivated and halogenated phenethylene derived amides, N-vinyl amides, and optically active substrates is noteworthy ...[more]