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Macrophages in breast cancer: do involution macrophages account for the poor prognosis of pregnancy-associated breast cancer?


ABSTRACT: Macrophage influx is associated with negative outcomes for women with breast cancer and has been demonstrated to be required for metastasis of mammary tumors in mouse models. Pregnancy-associated breast cancer is characterized by particularly poor outcomes, however the reasons remain obscure. Recently, post-pregnancy mammary involution has been characterized as having a wound healing signature. We have proposed the involution-hypothesis, which states that the wound healing microenvironment of the involuting gland is tumor promotional. Macrophage influx is one of the prominent features of the involuting gland, identifying the macrophage a potential instigator of tumor progression and a novel target for breast cancer treatment and prevention.

SUBMITTER: O'Brien J 

PROVIDER: S-EPMC2693782 | biostudies-other | 2009 Jun

REPOSITORIES: biostudies-other

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