Ontology highlight
ABSTRACT:
SUBMITTER: Kiso M
PROVIDER: S-EPMC2695080 | biostudies-other | 2009 Jun
REPOSITORIES: biostudies-other
Kiso Makoto M Tanaka Shigekazu S Saba Rie R Matsuda Satoru S Shimizu Atsushi A Ohyama Manabu M Okano Hirotaka James HJ Shiroishi Toshihiko T Okano Hideyuki H Saga Yumiko Y
Proceedings of the National Academy of Sciences of the United States of America 20090526 23
Hair is maintained through a cyclic process that includes periodic regeneration of hair follicles in a stem cell-dependent manner. Little is known, however, about the cellular and molecular mechanisms that regulate the layered differentiation of the hair follicle. We have established a mutant mouse with a cyclic alopecia phenotype resulting from the targeted disruption of Sox21, a gene that encodes a HMG-box protein. These mice exhibit progressive hair loss after morphogenesis of the first hair ...[more]