Ontology highlight
ABSTRACT:
SUBMITTER: Li Z
PROVIDER: S-EPMC2708864 | biostudies-other | 2009 Jun
REPOSITORIES: biostudies-other
Li Zhaoyong Z Hassan Mohammad Q MQ Jafferji Mohammed M Aqeilan Rami I RI Garzon Ramiro R Croce Carlo M CM van Wijnen Andre J AJ Stein Janet L JL Stein Gary S GS Lian Jane B JB
The Journal of biological chemistry 20090402 23
Bone tissue arises from mesenchymal cells induced into the osteoblast lineage by essential transcription factors and signaling cascades. MicroRNAs regulate biological processes by binding to mRNA 3'-untranslated region (UTR) sequences to attenuate protein synthesis. Here we performed microRNA profiling and identified miRs that are up-regulated through stages of osteoblast differentiation. Among these are the miR-29, miR-let-7, and miR-26 families that target many collagens and extracellular matr ...[more]