Ontology highlight
ABSTRACT:
SUBMITTER: Zhang Z
PROVIDER: S-EPMC2708869 | biostudies-other | 2009 Jun
REPOSITORIES: biostudies-other
Zhang Zhaohuan Z Xu Xiaohui X Zhang Yong Y Zhou Jianfeng J Yu Zhongwang Z He Cheng C
The Journal of biological chemistry 20090410 23
LINGO-1 is a component of the tripartite receptor complexes, which act as a convergent mediator of the intracellular signaling in response to myelin-associated inhibitors and lead to collapse of growth cone and inhibition of neurite extension. Although the function of LINGO-1 has been intensively studied, its downstream signaling remains elusive. In the present study, a novel interaction between LINGO-1 and a serine-threonine kinase WNK1 was identified by yeast two-hybrid screen. The interaction ...[more]