Ontology highlight
ABSTRACT:
SUBMITTER: Cai C
PROVIDER: S-EPMC2708885 | biostudies-other | 2009 Jun
REPOSITORIES: biostudies-other
Cai Chuanxi C Weisleder Noah N Ko Jae-Kyun JK Komazaki Shinji S Sunada Yoshihide Y Nishi Miyuki M Takeshima Hiroshi H Ma Jianjie J
The Journal of biological chemistry 20090420 23
Defective membrane repair can contribute to the progression of muscular dystrophy. Although mutations in caveolin-3 (Cav3) and dysferlin are linked to muscular dystrophy in human patients, the molecular mechanism underlying the functional interplay between Cav3 and dysferlin in membrane repair of muscle physiology and disease has not been fully resolved. We recently discovered that mitsugumin 53 (MG53), a muscle-specific TRIM (Tri-partite motif) family protein (TRIM72), contributes to intracellu ...[more]