Ontology highlight
ABSTRACT:
SUBMITTER: Sakata I
PROVIDER: S-EPMC2711663 | biostudies-other | 2009 Jul
REPOSITORIES: biostudies-other
Sakata Ichiro I Yang Jing J Lee Charlotte E CE Osborne-Lawrence Sherri S Rovinsky Sherry A SA Elmquist Joel K JK Zigman Jeffrey M JM
American journal of physiology. Endocrinology and metabolism 20090428 1
Ghrelin is a peptide hormone with many known functions, including orexigenic, blood glucose-regulatory, and antidepressant actions, among others. Mature ghrelin is unique in that it is the only known naturally occurring peptide to be posttranslationally modified by O-acylation with octanoate. This acylation is required for many of ghrelin's actions, including its effects on promoting increases in food intake and body weight. GOAT (ghrelin O-acyltransferase), one of 16 members of the MBOAT family ...[more]