Ontology highlight
ABSTRACT:
SUBMITTER: Saito Y
PROVIDER: S-EPMC2711840 | biostudies-other | 2009 Jun
REPOSITORIES: biostudies-other
Saito Yasuhiro Y Oinuma Izumi I Fujimoto Satoshi S Negishi Manabu M
EMBO reports 20090515 6
Plexins are receptors for axonal guidance molecules known as semaphorins. We recently reported that the semaphorin 4D (Sema4D) receptor, Plexin-B1, induces axonal growth cone collapse by functioning as an R-Ras GTPase activating protein (GAP). Here, we report that Plexin-B1 shows GAP activity for M-Ras, another member of the Ras family of GTPases. In cortical neurons, the expression of M-Ras was upregulated during dendritic development. Knockdown of endogenous M-Ras-but not R-Ras-reduced dendrit ...[more]