Ontology highlight
ABSTRACT:
SUBMITTER: Nagaraju G
PROVIDER: S-EPMC2715807 | biostudies-other | 2009 Aug
REPOSITORIES: biostudies-other
Nagaraju Ganesh G Hartlerode Andrea A Kwok Amy A Chandramouly Gurushankar G Scully Ralph R
Molecular and cellular biology 20090526 15
Sister chromatid recombination (SCR) is a potentially error-free pathway for the repair of DNA lesions associated with replication and is thought to be important for suppressing genomic instability. The mechanisms regulating the initiation and termination of SCR in mammalian cells are poorly understood. Previous work has implicated all the Rad51 paralogs in the initiation of gene conversion and the Rad51C/XRCC3 complex in its termination. Here, we show that hamster cells deficient in the Rad51 p ...[more]