Ontology highlight
ABSTRACT:
SUBMITTER: Kim J
PROVIDER: S-EPMC2717887 | biostudies-other | 2009 Aug
REPOSITORIES: biostudies-other
Kim Jayoung J Yanagihara Yutaka Y Kikugawa Tadahiko T Ji Mihee M Tanji Nozomu N Masayoshi Yokoyama Y Freeman Michael R MR
Endocrinology 20090514 8
Benign prostatic hyperplasia (BPH) is an age-related disease of unknown etiology characterized by prostatic enlargement and coinciding with distinctive alterations in tissue histomorphology. To identify the molecular mechanisms underlying the development of BPH, we conducted a DNA microarray study using a previously described animal model in which chronic alpha(1)-adrenergic stimulation by repeated administration of phenylephrine evokes histomorphological changes in the rat prostate that resembl ...[more]