Ontology highlight
ABSTRACT:
SUBMITTER: Yip L
PROVIDER: S-EPMC2718802 | biostudies-other | 2009 Jun
REPOSITORIES: biostudies-other
Yip Linda L Woehrle Tobias T Corriden Ross R Hirsh Mark M Chen Yu Y Inoue Yoshiaki Y Ferrari Vhe V Insel Paul A PA Junger Wolfgang G WG
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20090211 6
T-cell activation requires the influx of extracellular calcium, although mechanistic details regarding such activation are not fully defined. Here, we show that P2X(7) receptors play a key role in calcium influx and downstream signaling events associated with the activation of T cells. By real-time PCR and immunohistochemistry, we find that Jurkat T cells and human CD4(+) T cells express abundant P2X(7) receptors. We show, using a novel fluorescent microscopy technique, that T-cell receptor (TCR ...[more]