Ontology highlight
ABSTRACT:
SUBMITTER: Kawada J
PROVIDER: S-EPMC2719348 | biostudies-other | 2009 Jun
REPOSITORIES: biostudies-other
Kawada Junichi J Zou Ping P Mazitschek Ralph R Bradner James E JE Cohen Jeffrey I JI
The Journal of biological chemistry 20090422 25
Tubacin is a small molecule inhibitor of histone deacetylase 6 and blocks aggresome activity. We found that Epstein-Barr virus (EBV)-positive Burkitt lymphoma (BL) cells were generally killed by lower doses of tubacin than EBV-transformed lymphoblastoid cells (LCLs) or EBV-negative BL cells. Tubacin induced apoptosis of LCLs, which was inhibited by pretreatment with a pancaspase inhibitor but not by butylated hydroxyanisole, which inhibits reactive oxygen species. In contrast, tubacin killed EBV ...[more]