Epigenetic differences in cortical neurons from a pair of monozygotic twins discordant for Alzheimer's disease.
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ABSTRACT:
SUBMITTER: Mastroeni D
PROVIDER: S-EPMC2719870 | biostudies-other | 2009 Aug
REPOSITORIES: biostudies-other
Publications
Epigenetic differences in cortical neurons from a pair of monozygotic twins discordant for Alzheimer's disease.
Mastroeni Diego D McKee Ann A Grover Andrew A Rogers Joseph J Coleman Paul D PD
PloS one 20090812 8
DNA methylation is capable of modulating coordinate expression of large numbers of genes across many different pathways, and may therefore warrant investigation for their potential role between genes and disease phenotype. In a rare set of monozygotic twins discordant for Alzheimer's disease (AD), significantly reduced levels of DNA methylation were observed in temporal neocortex neuronal nuclei of the AD twin. These findings are consistent with the hypothesis that epigenetic mechanisms may medi ...[more]
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