STIMulating store-operated Ca(2+) entry.
Ontology highlight
ABSTRACT:
SUBMITTER: Cahalan MD
PROVIDER: S-EPMC2721799 | biostudies-other | 2009 Jun
REPOSITORIES: biostudies-other
Publications
Calcium influx through plasma membrane store-operated Ca(2+) (SOC) channels is triggered when the endoplasmic reticulum (ER) Ca(2+) store is depleted - a homeostatic Ca(2+) signalling mechanism that remained enigmatic for more than two decades. RNA-interference (RNAi) screening and molecular and cellular physiological analysis recently identified STIM1 as the mechanistic 'missing link' between the ER and the plasma membrane. STIM proteins sense the depletion of Ca(2+) from the ER, oligomerize, t ...[more]
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