Managing treatment-experienced pediatric and adolescent HIV patients: role of darunavir.
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ABSTRACT:
SUBMITTER: Neely M
PROVIDER: S-EPMC2724190 | biostudies-other | 2009 Jun
REPOSITORIES: biostudies-other
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Managing treatment-experienced pediatric and adolescent HIV patients: role of darunavir.
Neely Michael M Kovacs Andrea A
Therapeutics and clinical risk management 20090601 3
Darunavir is currently the most recently approved HIV-1 protease inhibitor. It is approved for twice-daily dosing with ritonavir in treatment-experienced patients as young as 6 years of age and is available in numerous pill strengths. Emergence of darunavir-specific mutations is generally slow; therefore it can retain activity against viral strains that are resistant to other protease inhibitors, including tipranavir. Darunavir pharmacokinetics, clinical efficacy, resistance mutations and pharma ...[more]
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