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A combined role of calcium channel blockers and angiotensin receptor blockers in stroke prevention.


ABSTRACT: Stroke is a leading cause of death and disability worldwide. The importance of lowering blood pressure for reducing the risk of stroke is well established. However, not all the benefits of antihypertensive treatments in stroke can be accounted for by reductions in BP and there may be differences between antihypertensive classes as to which provides optimal protection. Dihydropyridine calcium channel blockers, such as amlodipine, and angiotensin receptor blockers, such as valsartan, represent the two antihypertensive drug classes with the strongest supportive data for the prevention of stroke. Therefore, when combination therapy is required, a combination of these two antihypertensive classes represents a logical approach.

SUBMITTER: Wang JG 

PROVIDER: S-EPMC2725792 | biostudies-other | 2009

REPOSITORIES: biostudies-other

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A combined role of calcium channel blockers and angiotensin receptor blockers in stroke prevention.

Wang Ji-Guang JG  

Vascular health and risk management 20090806


Stroke is a leading cause of death and disability worldwide. The importance of lowering blood pressure for reducing the risk of stroke is well established. However, not all the benefits of antihypertensive treatments in stroke can be accounted for by reductions in BP and there may be differences between antihypertensive classes as to which provides optimal protection. Dihydropyridine calcium channel blockers, such as amlodipine, and angiotensin receptor blockers, such as valsartan, represent the  ...[more]

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