Ontology highlight
ABSTRACT:
SUBMITTER: Mani SA
PROVIDER: S-EPMC2728032 | biostudies-other | 2008 May
REPOSITORIES: biostudies-other
Cell 20080501 4
The epithelial-mesenchymal transition (EMT) is a key developmental program that is often activated during cancer invasion and metastasis. We here report that the induction of an EMT in immortalized human mammary epithelial cells (HMLEs) results in the acquisition of mesenchymal traits and in the expression of stem-cell markers. Furthermore, we show that those cells have an increased ability to form mammospheres, a property associated with mammary epithelial stem cells. Independent of this, stem ...[more]