The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores.
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ABSTRACT:
SUBMITTER: Irizarry RA
PROVIDER: S-EPMC2729128 | biostudies-other | 2009 Feb
REPOSITORIES: biostudies-other
Publications
The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores.
Irizarry Rafael A RA Ladd-Acosta Christine C Wen Bo B Wu Zhijin Z Montano Carolina C Onyango Patrick P Cui Hengmi H Gabo Kevin K Rongione Michael M Webster Maree M Ji Hong H Potash James J Sabunciyan Sarven S Feinberg Andrew P AP
Nature genetics 20090118 2
For the past 25 years, it has been known that alterations in DNA methylation (DNAm) occur in cancer, including hypomethylation of oncogenes and hypermethylation of tumor suppressor genes. However, most studies of cancer methylation have assumed that functionally important DNAm will occur in promoters, and that most DNAm changes in cancer occur in CpG islands. Here we show that most methylation alterations in colon cancer occur not in promoters, and also not in CpG islands, but in sequences up to ...[more]
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