Ontology highlight
ABSTRACT:
SUBMITTER: Clement CA
PROVIDER: S-EPMC2729259 | biostudies-other | 2009 Sep
REPOSITORIES: biostudies-other
Clement Christian A CA Kristensen Stine G SG Møllgård Kjeld K Pazour Gregory J GJ Yoder Bradley K BK Larsen Lars A LA Christensen Søren T ST
Journal of cell science 20090804 Pt 17
Defects in the assembly or function of primary cilia, which are sensory organelles, are tightly coupled to developmental defects and diseases in mammals. Here, we investigated the function of the primary cilium in regulating hedgehog signaling and early cardiogenesis. We report that the pluripotent P19.CL6 mouse stem cell line, which can differentiate into beating cardiomyocytes, forms primary cilia that contain essential components of the hedgehog pathway, including Smoothened, Patched-1 and Gl ...[more]