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Mathematical modeling supports substantial mouse neural progenitor cell death.

ABSTRACT: Existing quantitative models of mouse cerebral cortical development are not fully constrained by experimental data.Here, we use simple difference equations to model neural progenitor cell fate decisions, incorporating intermediate progenitor cells and initially low rates of neural progenitor cell death. Also, we conduct a sensitivity analysis to investigate possible uncertainty in the fraction of cells that divide, differentiate, and die at each cell cycle.We demonstrate that uniformly low-level neural progenitor cell death, as concluded in previous models, is incompatible with normal mouse cortical development. Levels of neural progenitor cell death up to and exceeding 50% are compatible with normal cortical development and may operate to prevent forebrain overgrowth as observed following cell death attenuation, as occurs in caspase 3-null mutant mice.

SUBMITTER: McConnell MJ

PROVIDER: S-EPMC2729736 | biostudies-other | 2009 Jul

REPOSITORIES: biostudies-other

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Mathematical modeling supports substantial mouse neural progenitor cell death.

McConnell Michael J MJ MacMillan Hugh R HR Chun Jerold J

Neural development 20090714

<h4>Background</h4>Existing quantitative models of mouse cerebral cortical development are not fully constrained by experimental data.<h4>Results</h4>Here, we use simple difference equations to model neural progenitor cell fate decisions, incorporating intermediate progenitor cells and initially low rates of neural progenitor cell death. Also, we conduct a sensitivity analysis to investigate possible uncertainty in the fraction of cells that divide, differentiate, and die at each cell cycle.<h4> ...[more]

PMID: 19602274

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