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Local origin of field potentials in visual cortex.

ABSTRACT: The local field potential (LFP) is increasingly used to measure the combined activity of neurons within a region of tissue. Yet, available estimates of the size of this region are highly disparate, ranging from several hundred microns to a few millimeters. To measure the size of this region directly, we used a combination of multielectrode recordings and optical imaging. We determined the orientation selectivity of stimulus-evoked LFP signals in primary visual cortex and were able to predict it on the basis of the surrounding map of orientation preference. The results show that > 95% of the LFP signal originates within 250 microm of the recording electrode. This quantitative estimate indicates that LFPs are more local than often recognized and provides a guide to the interpretation of the increasing number of studies that rest on LFP recordings.

SUBMITTER: Katzner S

PROVIDER: S-EPMC2730490 | biostudies-other | 2009 Jan

REPOSITORIES: biostudies-other

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Local origin of field potentials in visual cortex.

Katzner Steffen S Nauhaus Ian I Benucci Andrea A Bonin Vincent V Ringach Dario L DL Carandini Matteo M

Neuron 20090101 1

The local field potential (LFP) is increasingly used to measure the combined activity of neurons within a region of tissue. Yet, available estimates of the size of this region are highly disparate, ranging from several hundred microns to a few millimeters. To measure the size of this region directly, we used a combination of multielectrode recordings and optical imaging. We determined the orientation selectivity of stimulus-evoked LFP signals in primary visual cortex and were able to predict it ...[more]

PMID: 19146811

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