Ontology highlight
ABSTRACT:
SUBMITTER: Matheu MP
PROVIDER: S-EPMC2732399 | biostudies-other | 2008 Oct
REPOSITORIES: biostudies-other
Matheu Melanie P MP Beeton Christine C Garcia Adriana A Chi Victor V Rangaraju Srikant S Safrina Olga O Monaghan Kevin K Uemura Marc I MI Li Dan D Pal Sukumar S de la Maza Luis M LM Monuki Edwin E Flügel Alexander A Pennington Michael W MW Parker Ian I Chandy K George KG Cahalan Michael D MD
Immunity 20081002 4
Effector memory T (Tem) cells are essential mediators of autoimmune disease and delayed-type hypersensitivity (DTH), a convenient model for two-photon imaging of Tem cell participation in an inflammatory response. Shortly (3 hr) after entry into antigen-primed ear tissue, Tem cells stably attached to antigen-bearing antigen-presenting cells (APCs). After 24 hr, enlarged Tem cells were highly motile along collagen fibers and continued to migrate rapidly for 18 hr. Tem cells rely on voltage-gated ...[more]