Ontology highlight
ABSTRACT:
SUBMITTER: Sumner CJ
PROVIDER: S-EPMC2733819 | biostudies-other | 2009 Sep
REPOSITORIES: biostudies-other
Sumner Charlotte J CJ Wee Claribel D CD Warsing Leigh C LC Choe Dong W DW Ng Andrew S AS Lutz Cathleen C Wagner Kathryn R KR
Human molecular genetics 20090528 17
There is currently no treatment for the inherited motor neuron disease, spinal muscular atrophy (SMA). Severe SMA causes lower motor neuron loss, impaired myofiber development, profound muscle weakness and early mortality. Myostatin is a transforming growth factor-beta family member that inhibits muscle growth. Loss or blockade of myostatin signaling increases muscle mass and improves muscle strength in mouse models of primary muscle disease and in the motor neuron disease, amyotrophic lateral s ...[more]