Ontology highlight
ABSTRACT:
SUBMITTER: Autry AE
PROVIDER: S-EPMC2734472 | biostudies-other | 2009 Jul
REPOSITORIES: biostudies-other
Autry Anita E AE Adachi Megumi M Cheng Pengfei P Monteggia Lisa M LM
Biological psychiatry 20090409 1
<h4>Background</h4>Major depressive disorder is a leading debilitating disease known to occur at a two-fold higher rate in women than in men. The neurotrophic hypothesis of depression suggests that loss of brain-derived neurotrophic factor (BDNF) may increase susceptibility for depression-like behavior, although direct evidence is lacking.<h4>Methods</h4>Using the chronic unpredictable stress (CUS) paradigm, we investigated whether male and female mice with inducible BDNF deletion in the forebra ...[more]