Ontology highlight
ABSTRACT:
SUBMITTER: Sladewski TE
PROVIDER: S-EPMC2735492 | biostudies-other | 2009 Sep
REPOSITORIES: biostudies-other
Sladewski Thomas E TE Previs Michael J MJ Lord Matthew M
Molecular biology of the cell 20090701 17
We investigated the role of regulatory light-chain (Rlc1p) and heavy-chain phosphorylation in controlling fission yeast myosin-II (Myo2p) motor activity and function during cytokinesis. Phosphorylation of Rlc1p leads to a fourfold increase in Myo2p's in vitro motility rate, which ensures effective contractile ring constriction and function. Surprisingly, unlike with smooth muscle and nonmuscle myosin-II, RLC phosphorylation does not influence the actin-activated ATPase activity of Myo2p. A trunc ...[more]