Universal serial bus powered and controlled isolated constant-current physiological stimulator.
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ABSTRACT:
SUBMITTER: Holcomb MR
PROVIDER: S-EPMC2736648 | biostudies-other | 2008 Dec
REPOSITORIES: biostudies-other
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Project description:We have developed an isolated continuous-waveform constant-current physiological stimulator that is powered and controlled by universal serial bus (USB) interface. The stimulator is composed of a custom printed circuit board (PCB), 16-MHz MSP430F2618 microcontroller with two integrated 12-bit digital to analog converters (DAC0, DAC1), high-speed H-Bridge, voltage-controlled current source (VCCS), isolated USB communication and power circuitry, two isolated transistor-transistor logic (TTL) inputs, and a serial 16 × 2 character liquid crystal display. The stimulators are designed to produce current stimuli in the range of ±15 mA indefinitely using a 20V source and to be used in ex vivo cardiac experiments, but they are suitable for use in a wide variety of research or student experiments that require precision control of continuous waveforms or synchronization with external events. The device was designed with customization in mind and has features that allow it to be integrated into current and future experimental setups. Dual TTL inputs allow replacement by two or more traditional stimulators in common experimental configurations. The MSP430 software is written in C++ and compiled with IAR Embedded Workbench 5.20.2. A control program written in C++ runs on a Windows personal computer and has a graphical user interface that allows the user to control all aspects of the device.
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Project description:The golden ratio, ? = 1.61803…, has often been found in connection with biological phenomena, ranging from spirals in sunflowers to gene frequency. One example where the golden ratio often arises is in self-replication, having its mathematical origins in Fibonacci's sequence for "rabbit reproduction". Recently, it has been claimed that ? determines the ratio between the number of different nucleobases in human genome. Such empirical examples continue to give credence to the idea that the golden ratio is a universal constant, not only in mathematics but also for biology. In this paper, we employ a general framework for chemically realistic self-replicating reaction systems and investigate whether the ratio of chemical species population follows "universal constants". We find that many self-replicating systems can be characterised by an algebraic number, which, in some cases, is the golden ratio. However, many other algebraic numbers arise from these systems, and some of them-such as [Formula: see text] and 1.22074… which is also known as the 3rd lower golden ratio-arise more frequently in self-replicating systems than the golden ratio. The "universal constants" in these systems arise as roots of a limited number of distinct characteristic equations. In addition, these "universal constants" are transient behaviours of self-replicating systems, corresponding to the scenario that the resource inside the system is infinite, which is not always the case in practice. Therefore, we argue that the golden ratio should not be considered as a special universal constant in self-replicating systems, and that the ratios between different chemical species only go to certain numbers under some idealised scenarios.
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Project description:Constant-voltage and constant-current stimulators may be used for transcranial electrical stimulation of motor evoked potentials (TES-MEP). However, no previous report has determined whether the two monophasic stimulation methods lead to similar responses during intra-operative monitoring. We studied differences in the lateralities of compound muscle action potentials (CMAPs) during intra-operative spinal cord monitoring via TES-MEP using monophasic constant-current and constant-voltage stimulations. CMAPs were bilaterally recorded from the upper and lower limb muscles in 95 patients who underwent elective spine and spinal cord surgery. We used two monophasic stimulation patterns: pattern 1, right anode and left cathode; pattern 2, right cathode and left anode. There were no statistically significant differences between the right and left sides with respect to success rates, wave amplitudes, and efficiencies, with constant-voltage stimulation, however, there were statistically significant differences between the right and left sides with constant-current stimulation. In case of our stimulation condition, there were no statistically significant differences between the right and left sides with respect to CMAPs with constant-voltage stimulation; constant-current stimulation was influenced by the type of monophasic stimulation, which necessitates the switch the polarity of the stimulation to bilaterally record CMAPs.
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Project description:The global adoption of electric vehicles (EVs) is gaining momentum as countries strive to achieve sustainable development goals. Establishing charging infrastructure is of paramount importance to promote increased EV usage. The cost and weight of the batteries are factors that reduce the sales volume and popularity of EVs. A dynamic charging system has also been developed to enhance the driving range of EVs and mitigate the need for heavy storage requirements. The energy demand of charging infrastructure is increasing day by day. Many countries are installing solar arrays along the roadside to meet the power demand of highway lighting applications and achieve sustainable development goal (SDG) 7. To further enhance this system, this manuscript proposes integrating PV technology with the dynamic charging system. The PV arrays and energy storage system (ESS) collaborate to power the dynamic charging system. A multi-leg inverter is employed to energize the charging couplers, while a resonant network improves the power transfer capability of the couplers. On the receiver side, a resonant network ensures the delivery of constant voltage and constant current by tuning the network topology. The 3.3 kW five-legged inverter is developed to energize the four double-D-shaped charging couplers. The common DC bus delivers 350 V to the inverter, and the charging system delivers 350 V, 8.85 A to the EV batteries.
| S-EPMC11333607 | biostudies-literature
Project description:Introduction: Variable power output (VP) is one of the main characteristics of a road cycling mass-start. Tolerating VP during outdoor road cycling highly influences performance. There is a lack of continuous and comprehensive measurements during this power condition. Accordingly, the aim of the present study was to investigate physiological response to VP vs. constant power output (CP) as well as the perceived exertion of these two power conditions, and to investigate if variations in power output which span above lactate threshold (LT), differ from variations below LT. Methods: 15 elite competitive cyclists completed three test days, including 1 day of baseline testing and 2 days of main testing, consisting of four bouts of 28 min at two different intensities, "low" at 70% of LT and "high" at 95% of LT, with VP and CP. VP was performed with a 15% fluctuation of the average power output every second minute. Maximal oxygen uptake (VO2), respiratory exchange ratio (RER), heart rate (HR), blood lactate (LA), rating of perceived exertion (RPE), cadence (RPM) and power output (W) were measured. Results: At both low and high intensity, the VP condition induced a significantly higher VO2, HR and LA than the CP condition. Whole-bout RPE was similar between power conditions at high intensity. Additionally, at the high intensity, cycling with VP led to a greater increase in LA and lesser increase in RPE compared to cycling with CP. Discussion: The results of this study show that, despite considerable differences in the demand during the VP and CP bouts, there are minor differences in the perceptual and physiological response directly following these two power conditions in a cohort of elite competitive cyclists. A practical implication of these findings is that training with VP seems to be a viable alternative to training with CP, at least at high intensity.
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Project description:In situ conversion of mechanical energy into electricity is a feasible solution to satisfy the increasing power demand of the Internet of Things (IoTs). A triboelectric nanogenerator (TENG) is considered as a potential solution via building self-powered systems. Based on the triboelectrification effect and electrostatic induction, a conventional TENG with pulsed AC output characteristics always needs rectification and energy storage units to obtain a constant DC output to drive electronic devices. Here, we report a next-generation TENG, which realizes constant current (crest factor, ~1) output by coupling the triboelectrification effect and electrostatic breakdown. Meanwhile, a triboelectric charge density of 430 mC m-2 is attained, which is much higher than that of a conventional TENG limited by electrostatic breakdown. The novel DC-TENG is demonstrated to power electronics directly. Our findings not only promote the miniaturization of self-powered systems used in IoTs but also provide a paradigm-shifting technique to harvest mechanical energy.
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Project description:The spin current, orbit angular momentum current and total angular momentum current in a tensor form have been universally defined according to the quantum electrodynamics. Their conservation quantities and the continuity equations have been discussed in different cases. Non-relativistic approximation forms are deduced in order to explain their physical meanings, and to analyze some experimental results. The spin current of helical edge states in HgTe/CdTe quantum wells is calculated to demonstrate the properties of the spin current of the two dimensional quantum spin-Hall system. A generalized spin-orbit coupling term in the semiconducting media is deduced based on the theory of the electrodynamics in the moving media. It is recommended to use the effective total angular momentum current instead of the pure spin current to describe the distribution of polarization and the transport properties in spintronics.
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Project description:BackgroundThe city bus drivers have critical roles in public transport and are occupationally exposed to different environmental stressors. This study aimed to investigate body physiological responses of city bus drivers subjected to noise and vibration exposure while crossing city routes.MethodsThis cross-sectional study was conducted on 103 city bus drivers working in the governmental transportation system in Hamadan city. The subjects' exposures to noise and body vibration were measured during driving activities. Their blood pressure (BP), as well as heart rate (HR), were measured before and after driving. Multivariate regressions (MLR) were employed to analyze the effect size of the stimulus on body physiological responses using SPSS 22.ResultsExposure levels to noise, whole-body vibration (WBV), and hand-arm vibration among drivers were 79.50 ± 3.51dB, 0.620 ± 0.159 m/s2, and 0.438 ± 0.064 m/s2, respectively which were lower than the exposure limits. Heart rate as main physiological response before and after driving were 74.22 ± 4.11 and 79.23 ± 8.59 bpm, respectively. The developed MLR models statistically showed that noise exposure could only affect the HR (β = 0.193 and p < 0.001); while WBV exposure affected both BP (β = 0.360 and p < 0.001) and HR (β = 0.367 and p = 0.020). The statistical analysis represented that exposure to noise and vibration in the presence of other possible covariates have significant effects on body physiological responses.ConclusionThe study empirically confirmed the possibility of body physiological changes influenced by physical stimulus during real driving activities. It is highly recommended that occupational health surveillance should continuously be implemented to maintain and promote the safety and health of drivers throughout their careers.
| S-EPMC9434035 | biostudies-literature