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"Click, click, cyclize": a DOS approach to sultams utilizing vinyl sulfonamide linchpins.

ABSTRACT: A diversity-oriented synthesis (DOS) strategy termed "Click, Click, Cyclize" is reported. This approach relies on functional group (FG) pairing between a vinyl sulfonamide and an array of functional groups to synthesize skeletally diverse sultams. Several FG pairing pathways on central tertiary vinyl sulfonamide linchpins have been developed including intramolecular Heck, aza-Michael, ring-closing enyne metathesis, Pauson-Khand, and chemoselective oxidation/Baylis-Hillman reactions.

SUBMITTER: Zhou A

PROVIDER: S-EPMC2742886 | biostudies-other | 2009 Feb

REPOSITORIES: biostudies-other

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"Click, click, cyclize": a DOS approach to sultams utilizing vinyl sulfonamide linchpins.

Zhou Aihua A Rayabarapu Dinesh D Hanson Paul R PR

Organic letters 20090201 3

A diversity-oriented synthesis (DOS) strategy termed "Click, Click, Cyclize" is reported. This approach relies on functional group (FG) pairing between a vinyl sulfonamide and an array of functional groups to synthesize skeletally diverse sultams. Several FG pairing pathways on central tertiary vinyl sulfonamide linchpins have been developed including intramolecular Heck, aza-Michael, ring-closing enyne metathesis, Pauson-Khand, and chemoselective oxidation/Baylis-Hillman reactions. ...[more]

PMID: 19115841

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