Ontology highlight
ABSTRACT:
SUBMITTER: Kalaszczynska I
PROVIDER: S-EPMC2745999 | biostudies-other | 2009 Jul
REPOSITORIES: biostudies-other
Kalaszczynska Ilona I Geng Yan Y Iino Tadafumi T Mizuno Shin-ichi S Choi Yoon Y Kondratiuk Ilona I Silver Daniel P DP Wolgemuth Debra J DJ Akashi Koichi K Sicinski Piotr P
Cell 20090709 2
Cyclins are regulatory subunits of cyclin-dependent kinases. Cyclin A, the first cyclin ever cloned, is thought to be an essential component of the cell-cycle engine. Mammalian cells encode two A-type cyclins, testis-specific cyclin A1 and ubiquitously expressed cyclin A2. Here, we tested the requirement for cyclin A function using conditional knockout mice lacking both A-type cyclins. We found that acute ablation of cyclin A in fibroblasts did not affect cell proliferation, but led to prolonged ...[more]