Ontology highlight
ABSTRACT:
SUBMITTER: Grego-Bessa J
PROVIDER: S-EPMC2746361 | biostudies-other | 2007 Mar
REPOSITORIES: biostudies-other
Grego-Bessa Joaquín J Luna-Zurita Luis L del Monte Gonzalo G Bolós Victoria V Melgar Pedro P Arandilla Alejandro A Garratt Alistair N AN Zang Heesuk H Mukouyama Yoh-Suke YS Chen Hanying H Shou Weinian W Ballestar Esteban E Esteller Manel M Rojas Ana A Pérez-Pomares José María JM de la Pompa José Luis JL
Developmental cell 20070301 3
Ventricular chamber morphogenesis, first manifested by trabeculae formation, is crucial for cardiac function and embryonic viability and depends on cellular interactions between the endocardium and myocardium. We show that ventricular Notch1 activity is highest at presumptive trabecular endocardium. RBPJk and Notch1 mutants show impaired trabeculation and marker expression, attenuated EphrinB2, NRG1, and BMP10 expression and signaling, and decreased myocardial proliferation. Functional and molec ...[more]