Ontology highlight
ABSTRACT:
SUBMITTER: Rust MJ
PROVIDER: S-EPMC2748740 | biostudies-other | 2004 Jun
REPOSITORIES: biostudies-other
Rust Michael J MJ Lakadamyali Melike M Zhang Feng F Zhuang Xiaowei X
Nature structural & molecular biology 20040502 6
Most viruses enter cells via receptor-mediated endocytosis. However, the entry mechanisms used by many of them remain unclear. Also largely unknown is the way in which viruses are targeted to cellular endocytic machinery. We have studied the entry mechanisms of influenza viruses by tracking the interaction of single viruses with cellular endocytic structures in real time using fluorescence microscopy. Our results show that influenza can exploit clathrin-mediated and clathrin- and caveolin-indepe ...[more]