Ontology highlight
ABSTRACT:
SUBMITTER: van de Sluis B
PROVIDER: S-EPMC2750754 | biostudies-other | 2009 Oct
REPOSITORIES: biostudies-other
van de Sluis Bart B Groot Arjan J AJ Vermeulen Jeroen J van der Wall Elsken E van Diest Paul J PJ Wijmenga Cisca C Klomp Leo W LW Vooijs Marc M
PloS one 20091005 10
<h4>Background</h4>The Copper Metabolism MURR1 Domain containing 1 protein COMMD1 has been associated with copper homeostasis, NF-kappaB signaling, and sodium transport. Recently, we identified COMMD1 as a novel protein in HIF-1 signaling. Mouse embryos deficient for Commd1 have increased expression of hypoxia/HIF-regulated genes i.e. VEGF, PGK and Bnip3. Hypoxia-inducible factors (HIFs) are master regulators of oxygen homeostasis, which control angiogenesis, erythropoiesis, glycolysis and cell ...[more]