Ontology highlight
ABSTRACT:
SUBMITTER: Doi K
PROVIDER: S-EPMC2752080 | biostudies-other | 2009 Oct
REPOSITORIES: biostudies-other
The Journal of clinical investigation 20091001 10
Sepsis is characterized by a severe inflammatory response to infection, and its complications, including acute kidney injury, can be fatal. Animal models that correctly mimic human disease are extremely valuable because they hasten the development of clinically useful therapeutics. Too often, however, animal models do not properly mimic human disease. In this Review, we outline a bedside-to-bench-to-bedside approach that has resulted in improved animal models for the study of sepsis - a complex ...[more]