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Activation of innate immune antiviral responses by Nod2.

ABSTRACT: Pattern-recognition receptors (PRRs), including Toll-like receptors (TLRs) and RIG-like helicase (RLH) receptors, are involved in innate immune antiviral responses. Here we show that nucleotide-binding oligomerization domain 2 (Nod2) can also function as a cytoplasmic viral PRR by triggering activation of interferon-regulatory factor 3 (IRF3) and production of interferon-beta (IFN-beta). After recognition of a viral ssRNA genome, Nod2 used the adaptor protein MAVS to activate IRF3. Nod2-deficient mice failed to produce interferon efficiently and showed enhanced susceptibility to virus-induced pathogenesis. Thus, the function of Nod2 as a viral PRR highlights the important function of Nod2 in host antiviral defense mechanisms.

SUBMITTER: Sabbah A

PROVIDER: S-EPMC2752345 | biostudies-other | 2009 Oct

REPOSITORIES: biostudies-other

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Activation of innate immune antiviral responses by Nod2.

Sabbah Ahmed A Chang Te Hung TH Harnack Rosalinda R Frohlich Victoria V Tominaga Kaoru K Dube Peter H PH Xiang Yan Y Bose Santanu S

Nature immunology 20090823 10

Pattern-recognition receptors (PRRs), including Toll-like receptors (TLRs) and RIG-like helicase (RLH) receptors, are involved in innate immune antiviral responses. Here we show that nucleotide-binding oligomerization domain 2 (Nod2) can also function as a cytoplasmic viral PRR by triggering activation of interferon-regulatory factor 3 (IRF3) and production of interferon-beta (IFN-beta). After recognition of a viral ssRNA genome, Nod2 used the adaptor protein MAVS to activate IRF3. Nod2-deficien ...[more]

PMID: 19701189

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