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Functional consequence of plasmid DNA modified site-specifically with 7-deaza-deoxyadenosine at a single, programmable site.


ABSTRACT: Replacement of a single dA nucleotide positioned at a programmed site in a DNA plasmid with its 7-deaza-analog is described together with its complete resistance to restriction enzymatic cleavage.

SUBMITTER: Ang WH 

PROVIDER: S-EPMC2756714 | biostudies-other | 2009 Oct

REPOSITORIES: biostudies-other

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Functional consequence of plasmid DNA modified site-specifically with 7-deaza-deoxyadenosine at a single, programmable site.

Ang Wee Han WH   Lippard Stephen J SJ  

Chemical communications (Cambridge, England) 20090908 39


Replacement of a single dA nucleotide positioned at a programmed site in a DNA plasmid with its 7-deaza-analog is described together with its complete resistance to restriction enzymatic cleavage. ...[more]