Ontology highlight
ABSTRACT:
SUBMITTER: Meyer JS
PROVIDER: S-EPMC2757802 | biostudies-other | 2009 Sep
REPOSITORIES: biostudies-other
Meyer Jason S JS Shearer Rebecca L RL Capowski Elizabeth E EE Wright Lynda S LS Wallace Kyle A KA McMillan Erin L EL Zhang Su-Chun SC Gamm David M DM
Proceedings of the National Academy of Sciences of the United States of America 20090825 39
Human pluripotent stem cells have the potential to provide comprehensive model systems for the earliest stages of human ontogenesis. To serve in this capacity, these cells must undergo a targeted, stepwise differentiation process that follows a normal developmental timeline. Here we demonstrate the ability of both human embryonic stem cells (hESCs) and induced pluripotent stem (iPS) cells to meet these requirements for human retinogenesis. Upon differentiation, hESCs initially yielded a highly e ...[more]