Ontology highlight
ABSTRACT:
SUBMITTER: Lewis JC
PROVIDER: S-EPMC2757845 | biostudies-other | 2009 Sep
REPOSITORIES: biostudies-other
Lewis Jared C JC Bastian Sabine S Bennett Clay S CS Fu Yu Y Mitsuda Yuuichi Y Chen Mike M MM Greenberg William A WA Wong Chi-Huey CH Arnold Frances H FH
Proceedings of the National Academy of Sciences of the United States of America 20090915 39
Polysaccharides comprise an extremely important class of biopolymers that play critical roles in a wide range of biological processes, but the synthesis of these compounds is challenging because of their complex structures. We have developed a chemoenzymatic method for regioselective deprotection of monosaccharide substrates using engineered Bacillus megaterium cytochrome P450 (P450(BM3)) demethylases that provides a highly efficient means to access valuable intermediates, which can be converted ...[more]