Ontology highlight
ABSTRACT:
SUBMITTER: Lise MF
PROVIDER: S-EPMC2758809 | biostudies-other | 2009 Oct
REPOSITORIES: biostudies-other
Lisé Marie-France MF Srivastava Deepak P DP Arstikaitis Pamela P Lett Robyn L RL Sheta Razan R Viswanathan Vijay V Penzes Peter P O'Connor Timothy P TP El-Husseini Alaa A
Journal of cell science 20091001 Pt 20
Neuronal morphology plays an essential role in neuronal function. The establishment and maintenance of neuronal morphology is intimately linked to the actin cytoskeleton; however, the molecular mechanisms that regulate changes in neuronal morphology are poorly understood. Here we identify a novel myosin-Va (MyoVa)-interacting protein, RILPL2, which regulates cellular morphology. Overexpression of this protein in young or mature hippocampal neurons results in an increase in the number of spine-li ...[more]