Ontology highlight
ABSTRACT:
SUBMITTER: Tokito MK
PROVIDER: S-EPMC275970 | biostudies-other | 1996 Aug
REPOSITORIES: biostudies-other
Tokito M K MK Howland D S DS Lee V M VM Holzbaur E L EL
Molecular biology of the cell 19960801 8
P150Glued is the largest subunit of dynactin, which binds to cytoplasmic dynein and activates vesicle transport along microtubules. We have isolated human cDNAs encoding p150Glued as well as a 135-kDa isoform; these isoforms are expressed in human brain by alternative mRNA splicing of the human DCTN1 gene. The p135 isoform lacks the consensus microtubule-binding motif shared by members of the p150Glued/Glued/CLIP-170/BIK1 family of microtubule-associated proteins and, therefore, is predicted not ...[more]