Ontology highlight
ABSTRACT:
SUBMITTER: Keppler BR
PROVIDER: S-EPMC2761098 | biostudies-other | 2008 Nov
REPOSITORIES: biostudies-other
Keppler Brian R BR Archer Trevor K TK
Expert opinion on therapeutic targets 20081101 11
<h4>Background</h4>Part 1 of this review described the importance of histone acetylases, deacetylases, methylases and demethylases in transcriptional control and their potential as therapeutic targets. However, precise gene regulation requires the involvement of more than just the addition or removal of acetyl and methyl groups on histones. Histone phosphorylation, ubiquitylation, SUMOylation and poly-ADP-ribosylation, as well as ATP-dependent nucleosome remodeling complexes, play equally pivota ...[more]