Ontology highlight
ABSTRACT:
SUBMITTER: Lewis-Ballester A
PROVIDER: S-EPMC2765089 | biostudies-other | 2009 Oct
REPOSITORIES: biostudies-other
Lewis-Ballester Ariel A Batabyal Dipanwita D Egawa Tsuyoshi T Lu Changyuan C Lin Yu Y Marti Marcelo A MA Capece Luciana L Estrin Dario A DA Yeh Syun-Ru SR
Proceedings of the National Academy of Sciences of the United States of America 20090929 41
In contrast to the wide spectrum of cytochrome P450 monooxygenases, there are only 2 heme-based dioxygenases in humans: tryptophan dioxygenase (hTDO) and indoleamine 2,3-dioxygenase (hIDO). hTDO and hIDO catalyze the same oxidative ring cleavage reaction of L-tryptophan to N-formyl kynurenine, the initial and rate-limiting step of the kynurenine pathway. Despite immense interest, the mechanism by which the 2 enzymes execute the dioxygenase reaction remains elusive. Here, we report experimental e ...[more]