Novel inhibitors of the calcineurin/NFATc hub - alternatives to CsA and FK506?
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ABSTRACT:
SUBMITTER: Sieber M
PROVIDER: S-EPMC2774854 | biostudies-other | 2009
REPOSITORIES: biostudies-other
Publications
Novel inhibitors of the calcineurin/NFATc hub - alternatives to CsA and FK506?
Sieber Matthias M Baumgrass Ria R
Cell communication and signaling : CCS 20091027
The drugs cyclosporine A (CsA) and tacrolimus (FK506) revolutionized organ transplantation. Both compounds are still widely used in the clinic as well as for basic research, even though they have dramatic side effects and modulate other pathways than calcineurin-NFATc, too. To answer the major open question - whether the adverse side effects are secondary to the actions of the drugs on the calcineurin-NFATc pathway - alternative inhibitors were developed. Ideal inhibitors should discriminate bet ...[more]
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