Undisclosed changes in outcomes in randomized controlled trials: an observational study.
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ABSTRACT:
SUBMITTER: Ewart R
PROVIDER: S-EPMC2775624 | biostudies-other | 2009 Nov-Dec
REPOSITORIES: biostudies-other
Publications
Undisclosed changes in outcomes in randomized controlled trials: an observational study.
Ewart Robert R Lausen Harald H Millian Norman N
Annals of family medicine 20091101 6
<h4>Purpose</h4>We wanted to investigate the frequency of undisclosed changes in the outcomes of randomized controlled trials (RCTs) between trial registration and publication.<h4>Methods</h4>Using a retrospective, nonrandom, cross-sectional study design, we investigated RCTs published in consecutive issues of 5 major medical journals during a 6-month period and their associated trials registry entries. Articles were excluded if they did not have an available trial registry entry, did not have a ...[more]
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