The aberrant methylation of TSP1 suppresses TGF-beta1 activation in colorectal cancer.
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ABSTRACT:
SUBMITTER: Rojas A
PROVIDER: S-EPMC2777657 | biostudies-other | 2008 Jul
REPOSITORIES: biostudies-other
Publications
The aberrant methylation of TSP1 suppresses TGF-beta1 activation in colorectal cancer.
Rojas Andres A Meherem Shereen S Kim Young-Ho YH Washington Mary Kay MK Willis Joseph E JE Markowitz Sanford D SD Grady William M WM
International journal of cancer 20080701 1
Colorectal cancer arises from the progressive accumulation of mutations and epigenetic alterations in colon epithelial cells. Such alterations often deregulate signaling pathways that affect the formation of colon cancer, such as the Wnt, RAS-MAPK and TGF-beta pathways. The tumor promoting effects of mutations in genes, such as APC, have been demonstrated in cancer cell lines and in mouse models of intestinal cancer; however, the biological effects of most epigenetic events identified in colorec ...[more]
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