Heme oxygenase: the key to renal function regulation.
Ontology highlight
ABSTRACT:
SUBMITTER: Abraham NG
PROVIDER: S-EPMC2781329 | biostudies-other | 2009 Nov
REPOSITORIES: biostudies-other
Publications
Heme oxygenase: the key to renal function regulation.
Abraham Nader G NG Cao Jian J Sacerdoti David D Li Xiaoying X Drummond George G
American journal of physiology. Renal physiology 20090701 5
Heme oxygenase (HO) plays a critical role in attenuating the production of reactive oxygen species through its ability to degrade heme in an enzymatic process that leads to the production of equimolar amounts of carbon monoxide and biliverdin/bilirubin and the release of free iron. The present review examines the beneficial role of HO-1 (inducible form of HO) that is achieved by increased expression of this enzyme in renal tissue. The influence of the HO system on renal physiology, obesity, vasc ...[more]
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