Ontology highlight
ABSTRACT:
SUBMITTER: Ayoub MA
PROVIDER: S-EPMC2781458 | biostudies-other | 2009 Oct
REPOSITORIES: biostudies-other
Ayoub Mohammed Akli MA Damian Marjorie M Gespach Christian C Ferrandis Eric E Lavergne Olivier O De Wever Olivier O Banères Jean-Louis JL Pin Jean-Philippe JP Prévost Grégoire Pierre GP
The Journal of biological chemistry 20090731 42
The simultaneous activation of many distinct G protein-coupled receptors (GPCRs) and heterotrimeric G proteins play a major role in various pathological conditions. Pan-inhibition of GPCR signaling by small molecules thus represents a novel strategy to treat various diseases. To better understand such therapeutic approach, we have characterized the biomolecular target of BIM-46187, a small molecule pan-inhibitor of GPCR signaling. Combining bioluminescence and fluorescence resonance energy trans ...[more]